Obesity Linked to Myeloma Precursor
- March 5, 2024
A recent study published in Blood Advances highlights the potential link between modifiable risk factors and monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma. The study suggests that smoking and obesity may elevate the risk of developing MGUS, a condition where the blood contains higher than normal levels of a protein called M protein. Notably, the researchers propose a 73% increased likelihood of MGUS in individuals with obesity, although they caution that more research is necessary to establish a causative relationship. Multiple myeloma, an incurable cancer, often emerges after MGUS, making the identification of risk factors crucial for early intervention and prevention.
Dr. David Lee, a co-author of the study and an internal medicine resident at Massachusetts General Hospital, emphasizes the importance of investigating the risk factors and etiology of MGUS to better understand the population at increased risk for its development and progression to multiple myeloma. While the study delves into the association between obesity and MGUS, medical experts stress that other health complications related to obesity are more immediate and urgent for patient care.
Monoclonal gammopathy of undetermined significance is not considered a disease, and the risk of progression to myeloma is estimated to be about 1% per year. Experts caution individuals with obesity against excessive concern about their risk for MGUS and, subsequently, myeloma. Dr. Brian Durie, Chief Scientific Officer of the International Myeloma Foundation, suggests that addressing more imminent health risks associated with obesity, such as hypertension, diabetes, hyperlipidemia, stroke, and heart attack, is of greater urgency.
The study aims to guide further research into the role of modifiable risk factors and their impact on cancer risk. While lifestyle modifications in response to risk factors may be an avenue worth exploring in the future, physicians emphasize the current need for comprehensive approaches to address immediate health risks associated with obesity.
This is where diagnostic tools like Access Medical Labs’ Weight Loss Panel become essential. By assessing metabolic and hormonal factors influencing weight, they provide valuable insights for personalized interventions, allowing effective management of weight-related issues. Additionally, our Protein Electrophoresis test can contribute significantly to early detection and risk assessment of multiple myeloma. Integrating these panels into patient assessments can help physicians provide more targeted and comprehensive care, ultimately improving patient outcomes and overall well-being.
Access Medical Labs is your premier partner in diagnostic testing, providing cutting-edge solutions for healthcare professionals. Our simplified process means you receive your complimentary supplies directly to your office, and all you have to do is spin and send the specimens to our facility for next-day results. Spend less time on labs and more time with your patients. Register today for efficient and convenient diagnostic services.